NILES' WEEKLY REGISTER, Baltimore, July 27, 1822  

* Denmark Vesey slave rebellion... free black man in Charleston, SC
* The 1820  state-by-state slave population and projection for 1830
* Steamboat Robert Fulton, 1st built for ocean travel

The most historic item is found on the back page: a report of the Denmark Vesey slave revolt, noting that eight slaves were executed in Charleston.
The report has a small heading: "South Carolina", followed by updated particulars regarding the slave revolt. See photo for details.
Other notable coverage includes several pages dedicated to the current and projected state-by-sate population of the United States which indicates the changes in the population of slaves. 
There is also a brief mention of the steamboat "Robert Fulton", so-named in honor of its namesake. This was the first steamboat built for ocean travel. The mentioned journey was from New Orleans to New York.
Complete in sixteen pages, 6 1/4 by 9 3/4 inches, minor foxing, otherwise good.

A related post is also available on the History's Newsstand blog.

Background: Denmark Vesey was a formerly enslaved man who, after purchasing his freedom in 1799, became a skilled carpenter and respected community leader in Charleston, South Carolina. Deeply influenced by the ideals of the Haitian Revolution and the Biblical narratives of liberation, Vesey used his position within Charleston’s free Black community and the African Methodist Episcopal (AME) Church to organize a large-scale slave rebellion in 1822. His plan aimed to rally thousands of enslaved and free Black people to seize weapons, kill slaveholders, liberate the city, and escape to Haiti—a free Black republic at the time. The conspiracy was meticulously organized over several months, but it was betrayed by informants before it could be carried out. As a result, Vesey and 34 of his alleged co-conspirators were captured, tried in secret proceedings, and hanged, while many others were imprisoned or exiled. In the aftermath, white authorities clamped down on Black institutions, including destroying Vesey’s church, and enacted stricter laws to control the enslaved population. Though vilified in his time, Vesey is now remembered as a courageous symbol of Black resistance and the enduring fight against slavery and oppression in the United States.

As noted in Wikipedia, this title: "...(was) one of the most widely-circulated magazines in the United States...Devoted primarily to politics...considered an important source for the history of the period."