THE NEW YORK TIMES, May 21, 1943

* Marshall Admiral Isoroku Yamamoto killed
* Imperial Japanese Navy - combined fleet commander
* Attack on Pearl Harbor and Battle of Midway leader
* World War II - Pacific War

The front page has a one column heading: "JAPANESE ADMIRAL KILLED IN COMBAT" with subhead. (see images)
Complete with 40 pages, rag edition in great condition.