THE WEEKLY REGISTER, Baltimore, Sept. 7, 1811  

* Volume 1 number 1 issue 

This was the first issue published: "Vol. 1 No. 1" as noted in the masthead. The entire front page is taken up with: "The Editor To The Public" in which he details what the newspaper is to be about. Page 10 has a chart of: "Total Expenses, Of the War for Independence with a Statement of All the Troops in the Continental Service."
First issues remain desirable to collectors and even more so titles which would because extremely successful such as this one.
Sixteen pages, 6 by 9 1/2 inches, very nice condition.

background: This premier issue of the Niles’ Weekly Register, dated September 7, 1811, represents a foundational moment in American journalism and is a cornerstone for any serious historical collection. As the inaugural Volume 1, Number 1, it features Hezekiah Niles’ celebrated "The Editor To The Public" manifesto, which set a new standard for non-partisan, fact-based reporting in a young nation. Beyond its rarity as a first edition, the issue serves as a critical bridge between two eras; the detailed page 10 chart documenting the "Total Expenses" and troop counts of the Revolutionary War offered a sobering reflection on the cost of liberty just months before the outbreak of the War of 1812. Because this title evolved into one of the most influential and widely cited periodicals of the 19th century, this 16-page complete specimen is more than just a newspaper—it is a primary source document that captures the intellectual and political climate of the United States at the dawn of its first major global expansion.

As noted in Wikipedia, this title: "...(was) one of the most widely-circulated magazines in the United States...Devoted primarily to politics...considered an important source for the history of the period."