COLUMBIAN CENTINEL & MASSACHUSETTS FEDERALIST, Boston, Nov. 26,1803 

* Lewis and Clark Expedition begins
* Louisville, Kentucky - Ohio River

Page 2 has several items concerning the recent Louisiana Purchase, but certainly the most significant is a report from Louisville noting: "Capt. Clark, and Mr. Lewis, have left this place in the prosecution of their expedition to the westward. They have been sent thereon by the President of the United States. The object of their travels has not transpired. They will, it is said, ascent the Mississippi and Missouri as far s possible. they have an iron frame of a boat, intended to be covered with skins...About 60 men will compose the party."
Although there are other interesting items concerning Louisiana, they pale in comparison to this very significant report.
Four pages, minor foxing, nice condition.