NILES' WEEKLY REGISTER, Baltimore, Sept. 21, 1816  Nearly a full page has: "Gallipolis, Ohio" which provides a brief but historic background of this community.
Two separate articles illustrate a great contrast on relationships between various Indian Tribes and the new settlers: "Chickasaw Notice" and "Huntsville, (M.T.)". The former is a letter from William Colbert, general of the Chickasaws, beginning: "Brethren of the whites--It is with the most unfeigned pleasure that we contemplate the long & steady friendship subsisting between our nation & our American white brethren...".
The latter is a letter from the Cherokee Nation [then Mississippi Territory; Alabama became a state in 1817, carved out of the previous Miss. Territory] to colonel Richard Brown, who was also a Cherokee.
Sixteen pages, 6 by 9 1/2 inches, very nice condition

As noted in Wikipedia, this title: "...(was) one of the most widely-circulated magazines in the United States...Devoted primarily to politics...considered an important source for the history of the period."